Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.49 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.47 |
| ▸ | EEF2K | O00418 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077860 | 1.00 | GABBR2 (0.49) | GABBR2GABBR1FNTAFNTBHSD11B1 | |
| SCHEMBL8909238 | 0.89 | GABBR2 (0.56) | GABBR2GABBR1HSD11B1EEF2KMAPT | |
| SCHEMBL7073753 | 0.87 | GABBR2 (0.50) | GABBR2GABBR1HSD11B1EEF2KMAPT | |
| Ephedrine SCHEMBL7073757 | 0.86 | KMT2A (0.52) | GABBR2GABBR1FNTAFNTBHSD11B1 | |
| SCHEMBL7079059 | 0.85 | ALDH1A1 (0.45) | FNTAFNTBHSD11B1EEF2KMAPT | |
| SCHEMBL7080823 | 0.82 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL5278801 | 0.80 | BDKRB1 (0.47) | GABBR2GABBR1FNTAFNTBMAPT | |
| SCHEMBL7133113 | 0.80 | MEN1 (0.47) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL27603418 | 0.80 | HSD11B1 (0.51) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL6772429 | 0.78 | KMT2A (0.47) | FNTAFNTBHSD11B1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |