Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.50 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909238 | 0.91 | GABBR2 (0.56) | GABBR2GABBR1HSD11B1KDM4ERECQL | |
| SCHEMBL7077840 | 0.87 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7077860 | 0.87 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7073376 | 0.85 | ALDH1A1 (0.46) | HSD11B1MMP2ALDH1A1KMT2A | |
| SCHEMBL7080823 | 0.83 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7073896 | 0.83 | GABBR2 (0.39) | GABBR2GABBR1CA2MEN1KMT2A | |
| SCHEMBL5278801 | 0.81 | BDKRB1 (0.47) | GABBR2GABBR1KDM4EMAPTALDH1A1 | |
| SCHEMBL7133113 | 0.81 | MEN1 (0.47) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL27603418 | 0.81 | HSD11B1 (0.51) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7079926 | 0.76 | MAOA (0.48) | GABBR2GABBR1MMP2CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |