Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080823 | 0.90 | GABBR2 (0.49) | MEN1KMT2AGABBR2GABBR1MMP2 | |
| SCHEMBL8909238 | 0.83 | GABBR2 (0.56) | MEN1KMT2AGABBR2GABBR1MMP2 | |
| SCHEMBL7073753 | 0.81 | GABBR2 (0.50) | MEN1KMT2AGABBR2GABBR1MMP2 | |
| SCHEMBL7077860 | 0.80 | GABBR2 (0.49) | GABBR2GABBR1MMP2MMP1MMP3 | |
| SCHEMBL7077840 | 0.80 | GABBR2 (0.49) | GABBR2GABBR1MMP2MMP1MMP3 | |
| SCHEMBL7079926 | 0.77 | MAOA (0.48) | GABBR2GABBR1MMP2MMP1MMP3 | |
| SCHEMBL7077837 | 0.77 | ALDH1A1 (0.45) | MEN1KMT2AMMP2MMP3CA12 | |
| SCHEMBL7075400 | 0.75 | F2 (0.45) | MMP2MMP9MMP8CA12CA1 | |
| SCHEMBL7078814 | 0.75 | MMP13 (0.48) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL5278801 | 0.75 | BDKRB1 (0.47) | MEN1KMT2AGABBR2GABBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |