Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294115 | 0.86 | SLC6A3 (0.39) | KMT2AFPR2SCN9AMEN1HTT | |
| SCHEMBL7479568 | 0.86 | MT-CO2 (0.46) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL27824592 | 0.86 | HTT (0.35) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL7479440 | 0.86 | MT-CO2 (0.46) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL5846260 | 0.86 | KMT2A (0.40) | KMT2AMEN1KCNQ4KCNQ5HTT | |
| SCHEMBL8380101 | 0.86 | KMT2A (0.45) | KMT2AMEN1HTTNPSR1PLA2G1B | |
| SCHEMBL12813777 | 0.84 | ADRB2 (0.39) | KMT2AFPR2SCN9AMEN1HTT | |
| SCHEMBL7308442 | 0.84 | KMT2A (0.41) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL2861381 | 0.84 | XBP1 (0.37) | KMT2AMEN1HTTNPSR1PLA2G1B | |
| SCHEMBL7446003 | 0.84 | KMT2A (0.41) | KMT2AMEN1GAAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |