SCHEMBL8909753

SCHEMBL8909753

CC(Cc1ccccc1)(C(=O)O)S(=O)(=O)CC1CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 4/20 0.44
MMP13 P45452 4/20 0.44
MMP9 P14780 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.41
HIF1A Q16665 1/20 0.41
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KDM4E B2RXH2 1/20 0.37
SLC6A2 P23975 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27611648 0.76 SMN1; SMN2 (0.52) MMP1MMP13MMP9SMN1; SMN2HIF1A
SCHEMBL6929523 0.71 MMP1 (0.77) MMP1MMP13MMP9PPARGPPARA
SCHEMBL12913453 0.69 MMP13 (0.46) MMP1MMP13MMP9SMN1; SMN2HIF1A
SCHEMBL3818364 0.69 SMN1; SMN2 (0.55) SMN1; SMN2HIF1APPARGPPARAALDH1A1
SCHEMBL3818366 0.69 SMN1; SMN2 (0.55) SMN1; SMN2HIF1APPARGPPARAALDH1A1
Hydrochloric Acid SCHEMBL8909941 0.68 MMP1 (0.40) MMP1MMP13MMP9SMN1; SMN2HIF1A
SCHEMBL6933614 0.68 MMP1 (0.76) MMP1MMP13MMP9SMN1; SMN2HIF1A
SCHEMBL8710382 0.67 SMN1; SMN2 (0.57) SMN1; SMN2HIF1APPARGPPARAALDH1A1
SCHEMBL27908890 0.67 SMN1; SMN2 (0.57) SMN1; SMN2HIF1APPARGPPARAALDH1A1
SCHEMBL517462 0.67 SMN1; SMN2 (0.57) SMN1; SMN2HIF1APPARGPPARAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688946-A DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS HOFFMANN LA ROCHE INC. (US) 1997-11-18 US disclosed