Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818364 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL26664476 | 0.91 | BLM (0.52) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL3301635 | 0.83 | SLC6A2 (0.52) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL3301639 | 0.83 | SLC6A2 (0.52) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL27792993 | 0.82 | PPARA (0.55) | PPARGPPARASLC6A2CYP3A4CYP2C9 | |
| SCHEMBL26664449 | 0.80 | BLM (0.43) | SMN1; SMN2HIF1APPARGPPARACYP3A4 | |
| SCHEMBL28294369 | 0.80 | MMP8 (0.50) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL8710382 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL27908890 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2HIF1APPARGPPARASLC6A2 | |
| SCHEMBL517462 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2HIF1APPARGPPARASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483255-B1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | WYETH CORP (US) | 2009-08-12 | — | — | EP | disclosed |
| US-7091349-B2 | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1483255-A1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | Wyeth, A Corporation of the State of Delaware (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040230056-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH | 2004-11-18 | — | — | US | disclosed |
| US-6713626-B2 | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH | 2004-03-30 | — | — | US | disclosed |
| US-20030187265-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH | 2003-10-02 | — | — | US | disclosed |
| WO-2003078417-A1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | WYETH, A CORPORATION OF THE STATE OF DELAWARE (US) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040230056-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | TPH1, HTR1B, HTR1A | SMN1; SMN2 1936/4885HIF1A 2507/4885PPARG 1326/4885 |
| US-20030187265-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | TPH1, HTR1B, HTR1A | SMN1; SMN2 1936/4885HIF1A 2507/4885PPARG 1326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.