Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910755 | 0.87 | TSHR (0.33) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8910392 | 0.83 | CCNB2 (0.32) | LMNAMAPTHTT | |
| SCHEMBL8142537 | 0.83 | MYC (0.34) | MAPTHTTALDH1A1 | |
| SCHEMBL8148024 | 0.83 | TDP2 (0.40) | MAPTHTTCYP2C9CYP2C19 | |
| SCHEMBL8153428 | 0.81 | TP53 (0.36) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL8149803 | 0.80 | TP53 (0.37) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL8146061 | 0.80 | TP53 (0.37) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL8910285 | 0.80 | PARP10 (0.44) | MAPTALDH1A1 | |
| SCHEMBL8156114 | 0.80 | CHRM2 (0.38) | MAPTALDH1A1 | |
| SCHEMBL8536552 | 0.79 | GAA (0.32) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |