Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910147 | 0.87 | LMNA (0.31) | MAPTLMNAHTTPDK2HSP90AA1 | |
| SCHEMBL8142537 | 0.86 | MYC (0.34) | TSHRMAPTHTTKDM4EKMT2A | |
| SCHEMBL8910392 | 0.86 | CCNB2 (0.32) | MAPTLMNAHTTCCNB2CDK1 | |
| SCHEMBL8536552 | 0.84 | GAA (0.32) | MAPTLMNAHTTHSP90AA1SMN1; SMN2 | |
| SCHEMBL8148024 | 0.83 | TDP2 (0.40) | MAPTHTTPOLBMEN1KMT2A | |
| SCHEMBL8153428 | 0.83 | TP53 (0.36) | TSHRMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL8149803 | 0.82 | TP53 (0.37) | MAPTLMNAHTTSMN1; SMN2POLB | |
| SCHEMBL8156114 | 0.82 | CHRM2 (0.38) | MAPTKDM4EPOLBMEN1KMT2A | |
| SCHEMBL8146061 | 0.82 | TP53 (0.37) | MAPTLMNAHTTSMN1; SMN2POLB | |
| SCHEMBL8910285 | 0.82 | PARP10 (0.44) | MAPTKDM4EPOLBKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |