Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.44 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.33 |
| ▸ | ACR | P10323 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540291 | 0.85 | MYC (0.33) | KMT2AALDH1A1 | |
| SCHEMBL8909858 | 0.84 | MAPT (0.30) | MAPTKMT2A | |
| SCHEMBL8910755 | 0.82 | TSHR (0.33) | MAPTKDM4EPOLBKMT2AGAA | |
| SCHEMBL8148024 | 0.82 | TDP2 (0.40) | MAPTPOLBKMT2A | |
| SCHEMBL9057850 | 0.81 | MYC (0.36) | — | |
| SCHEMBL8910407 | 0.80 | BCHE (0.39) | KMT2AF2 | |
| SCHEMBL8910147 | 0.80 | LMNA (0.31) | MAPTALDH1A1 | |
| SCHEMBL8153428 | 0.76 | TP53 (0.36) | MAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL8146061 | 0.76 | TP53 (0.37) | MAPTPOLBKMT2AALDH1A1HPGD | |
| SCHEMBL8141070 | 0.75 | CHRNA7 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |