SCHEMBL6601809

SCHEMBL6601809

CN(C(=O)C(Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(Cc1ccc2ccccc2c1)c1nc(C(=O)O)no1

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 18/20 0.43
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27477312 1.00 TACR1 (0.43) TACR1MMP9MMP8
SCHEMBL6600882 0.90 MMP9 (0.42) TACR1MMP9MMP8
SCHEMBL2576148 0.90 TACR1 (0.40) TACR1MMP9MMP8
SCHEMBL6601553 0.90 MMP9 (0.40) TACR1MMP9MMP8
SCHEMBL6600255 0.86 YAP1 (0.45) TACR1
SCHEMBL6601864 0.85 TACR1 (0.39) TACR1MMP9MMP8
SCHEMBL6602096 0.84 CAPN1 (0.47) TACR1
SCHEMBL6600281 0.83 TACR1 (0.47) TACR1
SCHEMBL6602359 0.82 TACR1 (0.41) TACR1MMP9MMP8
SCHEMBL6604204 0.81 CTSS (0.53) TACR1MMP9MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1225471-C Compounds with growth hormone releasing properties NOVO NORDISK AS (DK) 2005-11-02 CN claimed
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP claimed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO claimed
CN-1225471-C Compounds with growth hormone releasing properties NOVO NORDISK AS (DK) 2005-11-02 CN disclosed
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
CN-1176645-A Compounds with growth hormone releasing properties NOVO NORDISK AS (DK) 1998-03-18 CN disclosed
EP-0805816-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-11-12 EP disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed