Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31465625 | 0.74 | LMNA (0.55) | LMNAPOLBSMN1; SMN2KMT2AHRH2 | |
| SCHEMBL8892471 | 0.73 | BDKRB2 (0.55) | BDKRB2SMN1; SMN2OPRK1OPRM1OPRD1 | |
| SCHEMBL14080050 | 0.69 | LMNA (0.52) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL4725898 | 0.69 | POLB (0.55) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL20919688 | 0.68 | LMNA (0.54) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL17144281 | 0.67 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2OPRK1OPRM1 | |
| SCHEMBL9405372 | 0.67 | POLB (0.73) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL17140529 | 0.67 | LMNA (0.41) | BDKRB2LMNAPOLBSMN1; SMN2OPRK1 | |
| SCHEMBL22345594 | 0.67 | SMN1; SMN2 (0.52) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL17144637 | 0.67 | LMNA (0.52) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |