Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121568 | 0.74 | TOP2A (0.41) | EGLN1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL7123595 | 0.62 | ALDH1A1 (0.41) | KDM4EMAPTKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL15971194 | 0.60 | CNR2 (0.41) | KDM4EMEN1KMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL21632762 | 0.59 | ACMSD (0.41) | KDM4EMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL11756192 | 0.59 | KDM4E (0.50) | KDM4EMEN1MAPTKMT2APTGDR2 | |
| Bicarbonate SCHEMBL9629020 | 0.59 | KMO (0.46) | KDM4EKMT2APTGDR2SMN1; SMN2HIF1A | |
| SCHEMBL8096676 | 0.58 | TOP2A (0.47) | CHRM1KDM4EMAPTLMNACYP1A2 | |
| SCHEMBL11374138 | 0.56 | KDM4E (0.50) | KDM4EMEN1MAPTKMT2APTGDR2 | |
| SCHEMBL9787018 | 0.55 | KDM4E (0.45) | NR1I2KDM4BCHRM1TBXA2RADRA1A | |
| SCHEMBL11335917 | 0.54 | KDM4E (0.44) | EGLN1KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |