Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MELK | Q14680 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913335 | 0.86 | KCNA5 (0.47) | KCNA5P2RX7FLT3MELKMAPK1 | |
| SCHEMBL8912797 | 0.85 | SLC1A3 (0.47) | KCNA5FLT3MELKMAPK1CAMKK2 | |
| SCHEMBL8913470 | 0.81 | HTT (0.50) | KCNA5MAPK1CYP3A4MMP2MMP9 | |
| SCHEMBL8914454 | 0.80 | P2RX7 (0.51) | P2RX7MELKMEN1KMT2APRKD3 | |
| SCHEMBL8912407 | 0.78 | MMP2 (0.67) | MEN1KMT2AMMP2MMP9ADAMTS4 | |
| SCHEMBL27146771 | 0.77 | MMP2 (0.59) | MEN1KMT2AMMP2MMP9ADAMTS4 | |
| SCHEMBL27146770 | 0.77 | MMP2 (0.59) | MEN1KMT2AMMP2MMP9ADAMTS4 | |
| SCHEMBL6522675 | 0.74 | MMP2 (0.66) | MMP2MMP9ADAMTS4 | |
| SCHEMBL8914953 | 0.74 | MMP2 (0.63) | TP53MMP2MMP9ADAMTS4 | |
| SCHEMBL7428005 | 0.73 | MELK (0.48) | KCNA5P2RX7FLT3MELKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |