Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.67 |
| ▸ | MMP9 | P14780 | 12/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.67 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.60 |
| ▸ | MMP1 | P03956 | 1/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.60 |
| ▸ | MMP7 | P09237 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916700 | 0.93 | MEN1 (0.60) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8914953 | 0.92 | MMP2 (0.63) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL697592 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL697591 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL4188026 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8916704 | 0.82 | MMP2 (0.58) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8913990 | 0.81 | ADAMTS4 (0.64) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL8913470 | 0.81 | HTT (0.50) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8915014 | 0.81 | MMP9 (0.73) | MMP2MMP9POLBMEN1KMT2A | |
| SCHEMBL6545297 | 0.81 | MMP2 (1.00) | MMP2MMP9ADAMTS4ADAMTS5MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |