Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 8/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914320 | 0.85 | BCAT2 (0.45) | ADAMTS4ITGAVALDH1A1BCAT2KDM4E | |
| SCHEMBL8912385 | 0.83 | KDM4E (0.48) | MMP2MMP9ADAMTS4KCNA5ALDH1A1 | |
| SCHEMBL8913898 | 0.81 | KCNA5 (0.47) | MMP2MMP9ADAMTS4KCNA5CYP3A4 | |
| SCHEMBL8912407 | 0.81 | MMP2 (0.67) | MMP2ADAMTS5MMP9ADAMTS4ALDH1A1 | |
| SCHEMBL8913765 | 0.79 | F2 (0.49) | HTTMMP2ADAMTS5MMP9ADAMTS4 | |
| SCHEMBL6522675 | 0.77 | MMP2 (0.66) | HTTMMP2ADAMTS5MMP9ADAMTS4 | |
| SCHEMBL8914953 | 0.77 | MMP2 (0.63) | MMP2ADAMTS5MMP9ADAMTS4ALDH1A1 | |
| SCHEMBL8916700 | 0.76 | MEN1 (0.60) | MMP2ADAMTS5MMP9ADAMTS4ITGAV | |
| SCHEMBL27146770 | 0.75 | MMP2 (0.59) | HTTMMP2ADAMTS5MMP9ADAMTS4 | |
| SCHEMBL27146771 | 0.75 | MMP2 (0.59) | HTTMMP2ADAMTS5MMP9ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |