Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.64 |
| ▸ | PRKCG | P05129 | 3/20 | 0.64 |
| ▸ | PRKCB | P05771 | 3/20 | 0.64 |
| ▸ | PRKCH | P24723 | 3/20 | 0.64 |
| ▸ | PRKCI | P41743 | 3/20 | 0.64 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.64 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.64 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.64 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.64 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8913358 | 0.84 | PRKD3 (0.87) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Bromide SCHEMBL8198354 | 0.82 | PRKD3 (0.82) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Bromide SCHEMBL8914119 | 0.81 | PRKD3 (0.64) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| SCHEMBL11203632 | 0.80 | PRKCA (0.54) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Iodide SCHEMBL8913120 | 0.80 | ADRA1D (0.53) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| SCHEMBL10960248 | 0.78 | CES2 (0.49) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Iodide SCHEMBL8915424 | 0.77 | PSMD14 (0.65) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| SCHEMBL10581460 | 0.73 | CES2 (0.44) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL10582011 | 0.72 | CES2 (0.42) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL9780292 | 0.72 | PSMD14 (0.45) | PRKCAPRKD3PRKCGPRKCBPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614548-A | TREATING TUMORS AND HIV INFECTION, PROTEIN KINASE C INHIBITORS | WAKE FOREST UNIVERSITY (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1990004918-A2 | QUATERNARY AMINE CONTAINING ETHER OR ESTER LIPID DERIVATIVES AND THERAPEUTIC COMPOSITIONS | WAKE FOREST UNIVERSITY (US) | 1990-05-17 | — | — | WO | disclosed |