Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.64 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.51 |
| ▸ | MMP9 | P14780 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914019 | 0.92 | ADAMTS4 (0.61) | ADAMTS4BCAT2MMP2MMP9MMP3 | |
| SCHEMBL8914187 | 0.88 | ADAMTS4 (0.66) | ADAMTS4BCAT2MMP2MMP9MMP3 | |
| SCHEMBL702794 | 0.82 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL790069 | 0.82 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL702793 | 0.82 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL8912407 | 0.81 | MMP2 (0.67) | ADAMTS4BCAT2MMP2MMP9MMP3 | |
| SCHEMBL8913118 | 0.80 | MMP2 (0.67) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL8914320 | 0.80 | BCAT2 (0.45) | ADAMTS4BCAT2ALDH1A1HSD17B10SLC1A3 | |
| SCHEMBL4651862 | 0.79 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL1751961 | 0.79 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| EP-0602028-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | PHARNO WEDROPHARM GMBH (DE) | 1994-06-22 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |