Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912385 | 0.90 | KDM4E (0.48) | BCAT2ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8913470 | 0.85 | HTT (0.50) | BCAT2ADAMTS4CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8913335 | 0.81 | KCNA5 (0.47) | BCAT2ALOX5APFEN1ADAMTS4SLC1A3 | |
| SCHEMBL8913990 | 0.80 | ADAMTS4 (0.64) | BCAT2ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8914019 | 0.75 | ADAMTS4 (0.61) | BCAT2ALOX5APFEN1ADAMTS4SLC1A3 | |
| SCHEMBL8914317 | 0.75 | CYP3A4 (0.46) | SLC1A3SLC1A2SLC1A1CYP3A4CYP1A2 | |
| SCHEMBL8912797 | 0.71 | SLC1A3 (0.47) | ADAMTS4SLC1A3SLC1A2SLC1A1CASP1 | |
| SCHEMBL8916278 | 0.71 | KDM4E (0.49) | BCAT2CASP1KDM4EPLAU | |
| SCHEMBL16000104 | 0.70 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL5136386 | 0.70 | BCAT2 (0.79) | BCAT2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |