Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.68 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.68 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.68 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.68 |
| ▸ | CDC25B | P30305 | 4/20 | 0.56 |
| ▸ | CDC25A | P30304 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.55 |
| ▸ | NSD2 | O96028 | 3/20 | 0.55 |
| ▸ | TDP2 | O95551 | 2/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.55 |
| ▸ | S100A4 | P26447 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11864498 | 0.83 | IDO1 (0.46) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL20046946 | 0.83 | IDO1 (0.58) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| Dichlon SCHEMBL45723 | 0.82 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL29941466 | 0.82 | CDC25B (0.68) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| Dichlon SCHEMBL9751236 | 0.82 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL571026 | 0.82 | CDC25B (0.68) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| Dichlon SCHEMBL29360991 | 0.82 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL9627428 | 0.80 | MEN1 (0.56) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| Dichlon SCHEMBL10794085 | 0.79 | IDO1 (0.94) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| Dichlon SCHEMBL28269079 | 0.79 | IDO1 (0.94) | IDO1DNMT1DNMT3LDNMT3ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180116977-A1 | NOVEL TREATMENT OF PROSTATE CARCINOMA | PELLFICURE PHARMACEUTICALS, INC. | 2018-05-03 | — | — | US | disclosed |
| US-9877932-B2 | Treatment of prostate carcinoma | PELLFICURE PHARMACEUTICALS, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170258744-A1 | NOVEL TREATMENT OF PROSTATE CARCINOMA | PELLFICURE PHARMACEUTICALS INC (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071940-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| WO-2017035501-A1 | SIALYLTRANSFERASE INHIBITORS AND USES THEREOF | ACADEMIA SINICA (TW) | 2017-03-02 | — | — | WO | disclosed |
| WO-2017020030-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-02-02 | — | — | WO | disclosed |
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| CN-1048619-A | The manufacture method of direct effect grand master pattern/pressing mold that light shows | DU PONT (US) | 1991-01-16 | — | — | CN | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |
| US-4507241-A | Method for the hydrocarbylation of naphthoquinone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, METAP2, DNPEP | IDO1 281/4885DNMT1 2961/4885DNMT3L 3466/4885 |
| US-20170258744-A1 | NOVEL TREATMENT OF PROSTATE CARCINOMA | KLK3, AR, PLK1 | IDO1 3276/4885DNMT1 4547/4885DNMT3L 4526/4885 |
| US-20180116977-A1 | NOVEL TREATMENT OF PROSTATE CARCINOMA | KLK3, AR, PLK1 | IDO1 3276/4885DNMT1 4547/4885DNMT3L 4526/4885 |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | IDO1 171/4885DNMT1 1736/4885DNMT3L 3021/4885 |
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | IDO1 171/4885DNMT1 1736/4885DNMT3L 3021/4885 |
| US-20170071940-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | IDO1 171/4885DNMT1 1736/4885DNMT3L 3021/4885 |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | USP1, USP2, USP28 | IDO1 2131/4885DNMT1 290/4885DNMT3L 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.