SCHEMBL8914910

SCHEMBL8914910

Cc1c(SCCN2CCCCC2)ccnc1CO

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.39
KDM4E B2RXH2 2/20 0.38
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
TSHR P16473 3/20 0.36
ALDH1A1 P00352 1/20 0.36
TAS2R14 Q9NYV8 1/20 0.36
TP53 P04637 1/20 0.35
HSD17B10 Q99714 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
LTA4H P09960 1/20 0.35
DRD2 P14416 1/20 0.35
DRD3 P35462 1/20 0.35
DCTPP1 Q9H773 1/20 0.35
HTT P42858 1/20 0.34
TMEM97 Q5BJF2 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8915212 0.88 KDM4E (0.43) KDM4EALDH1A1TP53HTT
SCHEMBL8914311 0.87 ALOX15 (0.39) ALOX15KDM4ECYP2C19HIF1ATSHR
SCHEMBL8916464 0.84 DRD3 (0.43) ALDH1A1HRH3DRD3MEN1KMT2A
SCHEMBL8915877 0.81 POLB (0.47) KDM4ETSHRALDH1A1HRH3HTT
SCHEMBL8914425 0.80 ALDH1A1 (0.52) KDM4EALDH1A1DRD2DRD3MEN1
SCHEMBL7005383 0.78 ALDH1A1 (0.35) KDM4EALDH1A1
SCHEMBL7011575 0.76 CA2 (0.34) CYP2C19ALDH1A1CYP1A2CYP3A4
SCHEMBL8916499 0.76 DRD4 (0.31)
SCHEMBL8918377 0.75 SIGMAR1 (0.42) KDM4EALDH1A1TP53HTT
SCHEMBL6869777 0.75 GSTP1 (0.35) KDM4ECYP2C19ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616581-A BACTERICIDES YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-04-01 US disclosed
US-5504082-A BACTERICIDE FOR HELICOBACTER, ANTIULCER AGENT, GASTRIC ACIDSUPPRESSOR YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1996-04-02 US disclosed
EP-0644191-A1 PYRIDINE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-03-22 EP disclosed