Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915243 | 0.93 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8917143 | 0.92 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8875496 | 0.91 | ALDH1A1 (0.45) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8767145 | 0.89 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8868488 | 0.88 | LMNA (0.51) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8875722 | 0.85 | ALDH1A1 (0.42) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8768242 | 0.84 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8875122 | 0.84 | ALDH1A1 (0.45) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8768265 | 0.84 | LMNA (0.44) | LMNAALDH1A1SMN1; SMN2MAPTNLRP3 | |
| SCHEMBL8867559 | 0.84 | NLRP3 (0.54) | LMNAALDH1A1MAPTNLRP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |