Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250342 | 0.81 | MAPT (0.41) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL521935 | 0.74 | NQO2 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL4723728 | 0.71 | NCF1 (0.44) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL558535 | 0.69 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL584784 | 0.69 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL558480 | 0.69 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL7060124 | 0.69 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL641339 | 0.69 | ALDH1A1 (0.47) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL269884 | 0.69 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL252593 | 0.69 | KDM4E (0.47) | MAPTALDH1A1HPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |