Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.58 |
| ▸ | MMP9 | P14780 | 7/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912407 | 0.82 | MMP2 (0.67) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8916700 | 0.80 | MEN1 (0.60) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL697592 | 0.78 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL4188026 | 0.78 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL697591 | 0.78 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL27463608 | 0.77 | MMP2 (0.62) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL6037682 | 0.77 | MMP2 (0.66) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL6037683 | 0.77 | MMP2 (0.66) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL19665787 | 0.76 | MMP2 (0.55) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL17822352 | 0.76 | MMP2 (0.55) | MMP2MMP9ADAMTS4ADAMTS5MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |