Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 9/20 | 0.58 |
| ▸ | MMP9 | P14780 | 7/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912407 | 0.93 | MMP2 (0.67) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL8914953 | 0.86 | MMP2 (0.63) | MMP2MMP9ADAMTS4ADAMTS5MMP1 | |
| SCHEMBL8912956 | 0.86 | L3MBTL1 (0.78) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL8916704 | 0.80 | MMP2 (0.58) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL697591 | 0.78 | MMP2 (0.85) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL4188026 | 0.78 | MMP2 (0.85) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL697592 | 0.78 | MMP2 (0.85) | MEN1KMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL8913990 | 0.78 | ADAMTS4 (0.64) | L3MBTL1MMP2MMP9ADAMTS4MMP1 | |
| SCHEMBL8915014 | 0.78 | MMP9 (0.73) | MEN1KMT2AMMP2MMP9POLB | |
| SCHEMBL8914187 | 0.76 | ADAMTS4 (0.66) | MMP2MMP9ADAMTS4MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |