Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902021 | 0.81 | HTR1A (0.52) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL29426374 | 0.78 | HTT (0.68) | KMT2AL3MBTL1HTTMAPTLMNA | |
| SCHEMBL3064690 | 0.78 | HTT (0.68) | KMT2AL3MBTL1HTTMAPTLMNA | |
| SCHEMBL8917679 | 0.78 | MET (0.66) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL10789091 | 0.77 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL14355885 | 0.74 | HTR1A (0.68) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL7598113 | 0.74 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL12932461 | 0.73 | HTT (0.61) | HTR1AKMT2AL3MBTL1HTTMAPT | |
| SCHEMBL14543394 | 0.72 | ALDH1A1 (0.68) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL17616635 | 0.72 | MAOB (0.52) | HTR1AADRA1DADRA1AADRA1BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |