Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD4 | P21917 | 8/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916897 | 0.95 | HTR1A (0.59) | DRD2DRD4DRD3ALDH1A1POLB | |
| SCHEMBL8991861 | 0.74 | HTR1A (0.54) | DRD2DRD4DRD3ALDH1A1POLB | |
| SCHEMBL3162686 | 0.73 | DRD2 (0.76) | DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8917302 | 0.73 | ALDH1A1 (0.52) | DRD2DRD4ALDH1A1POLBHTR1A | |
| SCHEMBL10864234 | 0.73 | DRD2 (0.60) | DRD2DRD4DRD3ALDH1A1POLB | |
| SCHEMBL8920666 | 0.73 | DRD2 (0.57) | DRD2DRD4DRD3HTR1AKMT2A | |
| Hydrochloric Acid SCHEMBL3165752 | 0.73 | DRD2 (0.75) | DRD2DRD4DRD3 | |
| SCHEMBL10863889 | 0.73 | DRD4 (0.65) | DRD2DRD4ALDH1A1POLBHTR1A | |
| Hydrochloric Acid SCHEMBL10838441 | 0.73 | HTR1A (0.65) | DRD2DRD4DRD3ALDH1A1POLB | |
| SCHEMBL3154864 | 0.72 | DRD2 (0.66) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691330-A | ANTIPSYCHOTIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |