Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8918026 | 0.97 | PDE10A (0.36) | PDE10AELANE | |
| Hydrochloric Acid SCHEMBL5352654 | 0.80 | HTR2A (0.47) | PDE10AHTR2A | |
| Hydrochloric Acid SCHEMBL8917342 | 0.80 | HTR2A (0.36) | PDE10AHTR2A | |
| Hydrochloric Acid SCHEMBL8917252 | 0.79 | HTR2A (0.42) | PDE10AHTR2A | |
| Hydrochloric Acid SCHEMBL6557592 | 0.75 | HTR2A (0.36) | PDE10AHTR2A | |
| Hydrochloric Acid SCHEMBL6559419 | 0.74 | MAPT (0.35) | PDE10AHTR2AMAPT | |
| SCHEMBL28398746 | 0.70 | ELANE (0.42) | HTR2AELANEMAPT | |
| Hydrochloric Acid SCHEMBL8174122 | 0.70 | HTR2A (0.54) | PDE10AHTR2A | |
| SCHEMBL633764 | 0.70 | HTR2A (0.58) | PDE10AHTR2A | |
| Hydrochloric Acid SCHEMBL8916641 | 0.70 | MEN1 (0.34) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |