Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL8917318

CCCC(=O)OC[C@H]1CCCN(C(=O)O)C1.O=C(O)C(F)(F)F

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
LMNA P02545 1/20 0.40
DPP8 Q6V1X1 6/20 0.37
DPP7 Q9UHL4 1/20 0.37
DPP4 P27487 5/20 0.36
LOXL2 Q9Y4K0 1/20 0.35
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
BCL9 O00512 1/20 0.34
CTNNB1 P35222 1/20 0.34
CNR1 P21554 1/20 0.34
MEN1 O00255 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
ALDH1A1 P00352 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8577553 0.92 LMNA (0.45) CHRNB2CHRNA4CHRNB4CHRNA3LMNA
SCHEMBL8719595 0.92 LMNA (0.45) CHRNB2CHRNA4CHRNB4CHRNA3LMNA
SCHEMBL8574640 0.92 LMNA (0.45) CHRNB2CHRNA4CHRNB4CHRNA3LMNA
Trifluoroacetic Acid SCHEMBL8578978 0.85 CHRNB2 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3DPP8
Trifluoroacetic Acid SCHEMBL8918909 0.82 DPP8 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3DPP8
SCHEMBL8574576 0.79 ALDH1A1 (0.47) BCHEMEN1MAPTKMT2AALDH1A1
SCHEMBL7289702 0.75 ALDH1A1 (0.42) LMNAPOLBALDH1A1
Trifluoroacetic Acid SCHEMBL8577300 0.74 DPP4 (0.39) LMNADPP8DPP4MEN1POLB
SCHEMBL22982975 0.74 ALDH1A1 (0.45) LMNAPOLBMAPTALDH1A1
SCHEMBL3655590 0.74 POLB (0.44) CHRNB2CHRNA4CHRNB4CHRNA3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5595999-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1997-01-21 US disclosed
US-5583133-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US disclosed
US-5532232-A INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD HOFFMANN-LA ROCHE INC. (US) 1996-07-02 US disclosed
US-5393760-A Cardiovascular disorders, antitumor agents HOFFMANN-LA ROCHE INC. (US) 1995-02-28 US disclosed
US-5260307-A Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma HOFMANN-LA ROCHE INC. (US) 1993-11-09 US disclosed