Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.34 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8917797 | 0.93 | PNMT (0.49) | MAP3K9MAP3K11PNMTELANEAPAF1 | |
| SCHEMBL8917078 | 0.79 | DRD2 (0.46) | PNMTELANEAPAF1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5363324 | 0.78 | PNMT (0.42) | MAP3K9MAP3K11PNMTHTR2ACHRM2 | |
| Hydrochloric Acid SCHEMBL5358974 | 0.75 | PNMT (0.42) | MAP3K9MAP3K11PNMTHTR2ACHRM2 | |
| Hydrochloric Acid SCHEMBL5352807 | 0.75 | MAP3K9 (0.39) | MAP3K9MAP3K11PNMTRAB9ACHRM2 | |
| SCHEMBL2310283 | 0.74 | PNMT (0.41) | MAP3K9MAP3K11PNMTALDH1A1MAPT | |
| SCHEMBL8151881 | 0.72 | PNMT (0.64) | PNMTELANEAPAF1ALDH1A1MAPT | |
| SCHEMBL22720620 | 0.72 | PNMT (0.46) | PNMTELANEAPAF1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5348072 | 0.72 | PNMT (0.68) | MAP3K9MAP3K11PNMTALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5351379 | 0.72 | MAP3K9 (0.39) | MAP3K9MAP3K11PNMTRAB9ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |