Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919777 | 0.88 | CHIA (0.42) | MEN1KMT2AL3MBTL1ALDH1A1GRIN2B | |
| Hydrochloric Acid SCHEMBL8919035 | 0.88 | GRIN2B (0.39) | MEN1KMT2AL3MBTL1ALDH1A1GRIN2B | |
| Hydrochloric Acid SCHEMBL8921524 | 0.86 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1GRIN2BKDM4E | |
| SCHEMBL8921489 | 0.85 | BRD4 (0.46) | MEN1KMT2AL3MBTL1GRIN2BNPSR1 | |
| SCHEMBL8919205 | 0.85 | HTT (0.45) | MEN1KMT2AL3MBTL1ALDH1A1GRIN2B | |
| SCHEMBL8922923 | 0.83 | CRBN (0.48) | ALDH1A1GRIN2BCHIAITGB3ITGA2B | |
| Oxalic Acid SCHEMBL8920376 | 0.83 | MEN1 (0.39) | MEN1KMT2AL3MBTL1ALDH1A1GRIN2B | |
| SCHEMBL9207045 | 0.81 | CCR3 (0.41) | MEN1KMT2AL3MBTL1GRIN2BCHIA | |
| Hydrochloric Acid SCHEMBL8918415 | 0.80 | CCR3 (0.41) | MEN1KMT2AL3MBTL1GRIN2BCHIA | |
| Oxalic Acid SCHEMBL8919236 | 0.79 | MEN1 (0.41) | MEN1KMT2AL3MBTL1ALDH1A1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |