Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | OGT | O15294 | 1/20 | 0.38 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8922908 | 0.86 | MAPK14 (0.41) | MEN1KMT2AGRIN2BCYP2C9CYP2C19 | |
| SCHEMBL8922923 | 0.86 | CRBN (0.48) | GRIN2BOGTCHIAALDH1A1CRBN | |
| SCHEMBL9207045 | 0.81 | CCR3 (0.41) | MEN1KMT2AL3MBTL1GRIN2BCYP2C9 | |
| SCHEMBL8919197 | 0.81 | CRBN (0.47) | GRIN2BOGTCRBNMAOAMAOB | |
| Hydrochloric Acid SCHEMBL8918415 | 0.80 | CCR3 (0.41) | MEN1KMT2AL3MBTL1GRIN2BCYP2C9 | |
| Hydrochloric Acid SCHEMBL8919035 | 0.80 | GRIN2B (0.39) | MEN1KMT2AL3MBTL1GRIN2BCHIA | |
| Oxalic Acid SCHEMBL8919232 | 0.79 | MEN1 (0.41) | MEN1KMT2AL3MBTL1GRIN2BCHIA | |
| SCHEMBL8919246 | 0.78 | L3MBTL1 (0.38) | MEN1KMT2AL3MBTL1GRIN2BCYP2C9 | |
| Hydrochloric Acid SCHEMBL7470903 | 0.77 | HSD11B1 (0.47) | GRIN2BCHIACRBN | |
| SCHEMBL8919777 | 0.77 | CHIA (0.42) | MEN1KMT2AL3MBTL1GRIN2BCHIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |