Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928013 | 0.72 | MAPT (0.40) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9508261 | 0.72 | MEN1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL22187492 | 0.72 | CA2 (0.63) | POLBCA2CA1CA9CA12 | |
| SCHEMBL1177112 | 0.68 | POLB (0.49) | POLBENPP1ENPP2ENPP3LMNA | |
| SCHEMBL9508266 | 0.68 | KMT2A (0.39) | POLBCA2CA1CA9CA12 | |
| SCHEMBL22187371 | 0.68 | ENPP1 (0.57) | POLBCA2CA1CA9CA12 | |
| SCHEMBL8928012 | 0.68 | CA2 (0.48) | POLBCA2CA1CA9CA12 | |
| SCHEMBL22187161 | 0.67 | CA2 (0.56) | POLBCA2CA1CA9CA12 | |
| SCHEMBL30579835 | 0.67 | CA2 (0.56) | POLBCA2CA1CA9CA12 | |
| SCHEMBL15444335 | 0.66 | MAPT (0.59) | POLBLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758681-A2 | Inhibiting transformation of cells having elevated purine metabolic enzyme activity | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-02-19 | — | — | EP | disclosed |