Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714638 | 0.81 | TTR (0.51) | MAPTPOLBL3MBTL1KDM4EKDM1A | |
| SCHEMBL9508266 | 0.81 | KMT2A (0.39) | MAPTKMT2APOLBL3MBTL1KDM4E | |
| SCHEMBL2177285 | 0.79 | SNCA (0.50) | MAPTKMT2APOLBL3MBTL1KDM4E | |
| SCHEMBL10563277 | 0.74 | ABCC9 (0.54) | MAPTKMT2APOLBKDM4EMEN1 | |
| SCHEMBL10901227 | 0.74 | CTRB1 (0.46) | MAPTKMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL9338089 | 0.73 | CTRB1 (0.44) | KDM4ECTRB1GAARAB9ACYP1A2 | |
| SCHEMBL11442245 | 0.73 | MEN1 (0.48) | MAPTKMT2AKDM4EMEN1CTRB1 | |
| SCHEMBL10354309 | 0.72 | CTRB1 (0.47) | CTRB1ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8919664 | 0.72 | POLB (0.46) | MAPTKMT2APOLBLMNAMEN1 | |
| SCHEMBL7194449 | 0.72 | SNCA (0.51) | MAPTKMT2APOLBL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458901-B1 | INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY | MASSACHUSETTS INST TECHNOLOGY (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5324731-A | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated | AMIRA, INC. (US) | 1994-06-28 | — | — | US | disclosed |