Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 6/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9133694 | 0.87 | ALOX15 (0.43) | HPGDALDH1A1HSD17B10ALOX15NOTUM | |
| SCHEMBL8921644 | 0.87 | ALDH1A1 (0.57) | HPGDALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL9133737 | 0.87 | ALDH1A1 (0.41) | HPGDALDH1A1HSD17B10ALOX15NOTUM | |
| SCHEMBL8921982 | 0.86 | ALDH1A1 (0.47) | HPGDALDH1A1HSD17B10ALOX15CNR1 | |
| SCHEMBL8921531 | 0.86 | ALDH1A1 (0.54) | HPGDALDH1A1HSD17B10ALOX15FABP3 | |
| SCHEMBL9857787 | 0.81 | CNR1 (0.37) | HPGDALDH1A1HSD17B10ALOX15CNR1 | |
| SCHEMBL8923331 | 0.75 | HPGD (0.56) | HPGDALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL8922043 | 0.75 | ALDH1A1 (0.67) | HPGDALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL9243444 | 0.74 | ALDH1A1 (0.45) | HPGDALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL9132101 | 0.74 | HPGD (0.57) | HPGDALDH1A1HSD17B10ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | claimed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | claimed |
| EP-0431371-A1 | 3-Aminopyrroles, process for this preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-06-12 | — | — | EP | claimed |
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | disclosed |