SCHEMBL8920105

SCHEMBL8920105

CCc1ccc2c(c1)C(CCC1c3cc(CC)ccc3-c3ccc(CC)cc31)c1cc(CC)ccc1-2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TRPA1 O75762 1/20 0.40
CYP2A6 P11509 2/20 0.39
CYP1A2 P05177 1/20 0.39
PDK2 Q15119 1/20 0.34
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
GAA P10253 3/20 0.33
KDM4E B2RXH2 2/20 0.33
BRD4 O60885 1/20 0.33
HPGD P15428 1/20 0.33
KIF11 P52732 2/20 0.32
NOS3 P29474 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7605720 0.89 NPC1 (0.47) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
Hydrochloric Acid SCHEMBL5351575 0.88 NPC1 (0.46) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL31026796 0.83 TRPA1 (0.42) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL27355090 0.79 NPC1 (0.49) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL5082800 0.78 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
Hydrochloric Acid SCHEMBL17698553 0.77 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
Hydrochloric Acid SCHEMBL3683321 0.77 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL3683324 0.74 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL8917213 0.73 MAOA (0.37) ALDH1A1SMN1; SMN2NPC1TRPA1CYP2A6
SCHEMBL12017104 0.71 NPC1 (0.49) ALDH1A1SMN1; SMN2NPC1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5668230-A METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST PHILLIPS PETROLEUM COMPANY (US) 1997-09-16 US disclosed