Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917550 | 0.90 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL9231677 | 0.79 | CA1 (0.58) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL8916189 | 0.76 | PTGS2 (0.52) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL9234798 | 0.76 | PTGS2 (0.52) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL9235122 | 0.76 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL9233583 | 0.76 | PTGS2 (0.52) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL8917392 | 0.76 | PTGS2 (0.57) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL8917741 | 0.73 | CA9 (0.52) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL8918668 | 0.68 | CA12 (0.46) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL8916244 | 0.67 | PTGS2 (0.42) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |