Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 12/20 | 0.52 |
| ▸ | CA1 | P00915 | 7/20 | 0.52 |
| ▸ | CA2 | P00918 | 7/20 | 0.52 |
| ▸ | CA4 | P22748 | 6/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917392 | 0.92 | PTGS2 (0.57) | CA9CA1CA2CA4PTGS1 | |
| SCHEMBL8920714 | 0.91 | PTGS2 (0.46) | CA9CA1CA2CA4CHRNA7 | |
| SCHEMBL8916189 | 0.88 | PTGS2 (0.52) | CA9CA1CA2CA4PTGS1 | |
| SCHEMBL9234798 | 0.88 | PTGS2 (0.52) | CA9CA1CA2CA4PTGS1 | |
| SCHEMBL8917527 | 0.83 | PTGS2 (0.45) | PTGS1PTGS2MAPTALDH1A1 | |
| SCHEMBL8916244 | 0.80 | PTGS2 (0.42) | PTGS1PTGS2 | |
| SCHEMBL9229223 | 0.79 | PTGS2 (0.40) | PTGS1PTGS2MAPTADORA1 | |
| SCHEMBL9235122 | 0.78 | PTGS2 (0.54) | PTGS1PTGS2 | |
| SCHEMBL9233583 | 0.78 | PTGS2 (0.52) | CA9CA1CA2PTGS1PTGS2 | |
| SCHEMBL8317147 | 0.75 | PTGS2 (0.80) | CA9CA1CA2CA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |