Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916189 | 0.92 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL9229223 | 0.90 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL8917527 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL8920714 | 0.87 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL8917392 | 0.83 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL9234798 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8917741 | 0.80 | CA9 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8918689 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8918668 | 0.76 | CA12 (0.46) | PTGS2PTGS1LRRK2 | |
| SCHEMBL6353757 | 0.75 | CCNA2 (0.44) | PTGS2PTGS1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009293-A1 | BENZ[g]INDAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | claimed |
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |
| WO-1996009293-A1 | BENZ[g]INDAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |