Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 3/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921392 | 0.90 | PLA2G10 (0.35) | CCKBRPLA2G10PLA2G5L3MBTL1OPRM1 | |
| SCHEMBL8919489 | 0.90 | L3MBTL1 (0.37) | CCKBRPLA2G10PLA2G5L3MBTL1GPR119 | |
| SCHEMBL8920349 | 0.87 | RAMP1 (0.42) | CCKBRPLA2G10PLA2G5MEN1KMT2A | |
| SCHEMBL8921138 | 0.84 | PLA2G10 (0.45) | CCKBRPLA2G10PLA2G5L3MBTL1MEN1 | |
| SCHEMBL8920820 | 0.81 | CCKBR (0.40) | CCKBRPLA2G10PLA2G5L3MBTL1KMT2A | |
| SCHEMBL8922628 | 0.80 | PLA2G10 (0.35) | CCKBRPLA2G10PLA2G5L3MBTL1ALDH1A1 | |
| SCHEMBL8921163 | 0.79 | CCKBR (0.38) | CCKBRPLA2G10PLA2G5OPRM1MEN1 | |
| SCHEMBL8975503 | 0.79 | CCR2 (0.36) | PLA2G10PLA2G5OPRM1OPRL1MEN1 | |
| SCHEMBL8920178 | 0.78 | CCKBR (0.46) | CCKBRPLA2G10PLA2G5 | |
| SCHEMBL8921722 | 0.77 | RAMP1 (0.41) | CCKBRPLA2G10PLA2G5MAPTRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |