Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920807 | 0.90 | CCKBR (0.37) | PLA2G10PLA2G5ALDH1A1CCKBRL3MBTL1 | |
| SCHEMBL8922628 | 0.90 | PLA2G10 (0.35) | PLA2G10PLA2G5ALDH1A1CCKBRTP53 | |
| SCHEMBL8921722 | 0.87 | RAMP1 (0.41) | PLA2G10PLA2G5CCKBRTP53MDM2 | |
| SCHEMBL8919489 | 0.80 | L3MBTL1 (0.37) | PLA2G10PLA2G5ALDH1A1CCKBRL3MBTL1 | |
| SCHEMBL8923886 | 0.79 | CCKBR (0.42) | PLA2G10PLA2G5CCKBRTP53MDM2 | |
| SCHEMBL8921163 | 0.79 | CCKBR (0.38) | PLA2G10PLA2G5ALDH1A1CCKBRTP53 | |
| SCHEMBL8975503 | 0.78 | CCR2 (0.36) | PLA2G10PLA2G5ALDH1A1OPRM1OPRL1 | |
| SCHEMBL8920349 | 0.77 | RAMP1 (0.42) | PLA2G10PLA2G5ALDH1A1CCKBRTP53 | |
| SCHEMBL8920743 | 0.76 | RAMP1 (0.41) | PLA2G10PLA2G5ALDH1A1CCKBRGHSR | |
| SCHEMBL8921199 | 0.76 | PLA2G10 (0.42) | PLA2G10PLA2G5ALDH1A1CCKBRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |