SCHEMBL8920969

SCHEMBL8920969

N=C1NC2(OCCO2)c2cc(Cl)ccc21

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AKR1A1 P14550 2/20 0.37
AKR1B1 P15121 2/20 0.37
PPOX P50336 1/20 0.37
CES1 P23141 1/20 0.34
PDK2 Q15119 1/20 0.34
PDE7A Q13946 1/20 0.34
PGR P06401 1/20 0.33
ANPEP P15144 1/20 0.33
AKR1C3 P42330 1/20 0.33
TDP2 O95551 1/20 0.33
GSK3A P49840 1/20 0.32
GSK3B P49841 1/20 0.32
POLB P06746 1/20 0.32
F7 P08709 1/20 0.32
PARP1 P09874 1/20 0.32
F3 P13726 1/20 0.32
PARP10 Q53GL7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8918847 0.87 PPOX (0.37) AKR1A1AKR1B1PPOXCES1PDK2
SCHEMBL8920976 0.78 AKR1B1 (0.36) AKR1A1AKR1B1PPOXPDK2PDE7A
SCHEMBL8920932 0.77 PDE7A (0.38) AKR1B1PDK2PDE7ATDP2
SCHEMBL8918252 0.75 TDP2 (0.46) AKR1B1PGRTDP2POLB
SCHEMBL8919892 0.71 PDE7A (0.35) AKR1A1AKR1B1PDE7A
SCHEMBL7827374 0.70 AKR1B1 (0.39) AKR1A1AKR1B1PPOXCES1PDK2
SCHEMBL8919799 0.69 NSD2 (0.35) CES1PDE7AGSK3AGSK3B
SCHEMBL8917662 0.68 CES1 (0.34) CES1PDK2PDE7AAKR1C3
SCHEMBL8918874 0.66 TDP1 (0.45) PGRTDP2GSK3AGSK3BPOLB
SCHEMBL7828075 0.66 AKR1B1 (0.36) AKR1A1AKR1B1PPOXPDK2PDE7A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691272-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1997-11-25 US disclosed
US-5559247-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1996-09-24 US disclosed
EP-0679640-A1 Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-11-02 EP disclosed