Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSG | P08311 | 2/20 | 0.52 |
| ▸ | CMA1 | P23946 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 4/20 | 0.51 |
| ▸ | ACE | P12821 | 4/20 | 0.51 |
| ▸ | CPA1 | P15085 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | FCER2 | P06734 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921872 | 1.00 | CTSG (0.52) | CTSGCMA1MMEACECPA1 | |
| SCHEMBL3628827 | 0.86 | MME (0.56) | MMEACECPA1ACE2TACR1 | |
| SCHEMBL4291672 | 0.84 | CTSG (0.65) | CTSGCMA1MMEACE | |
| SCHEMBL6942656 | 0.84 | CTSG (0.65) | CTSGCMA1MMEACE | |
| SCHEMBL5664274 | 0.84 | CTSG (0.65) | CTSGCMA1MMEACE | |
| SCHEMBL2345995 | 0.80 | MMP9 (0.47) | MMEACECPA1ACE2TACR1 | |
| SCHEMBL2343629 | 0.80 | MME (0.50) | MMEACECPA1ACE2TACR1 | |
| SCHEMBL8201136 | 0.78 | FCER2 (0.69) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL8201134 | 0.78 | FCER2 (0.69) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL8918692 | 0.77 | TACR1 (0.46) | MMEACECPA1ACE2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652369-A | PROTEASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5554756-A | PROTEASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1996-09-10 | — | — | US | disclosed |
| US-5446161-A | Protease inhibitor, viricides | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |