SCHEMBL8922243

SCHEMBL8922243

Nc1c(C(F)(F)F)cc(-c2cc(C(F)(F)F)c(N)c(C(F)(F)C(F)(F)F)c2)cc1C(F)(F)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.35
TSHR P16473 1/20 0.35
KIF11 P52732 1/20 0.34
PIK3CD O00329 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MPL P40238 2/20 0.32
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993265 0.88 TSHR (0.42) GLAPOLBGAATSHRKIF11
SCHEMBL7992614 0.78 CA1 (0.32) KDM4EMEN1LMNAMAPTMAPK1
SCHEMBL5987423 0.77 KDM4E (0.33) GLAPOLBGAATSHRKIF11
SCHEMBL28945538 0.76 KIF11 (0.60) GLAPOLBGAATSHRKIF11
SCHEMBL28674664 0.76 KIF11 (0.46) GLAPOLBGAATSHRKIF11
SCHEMBL5669382 0.73 HSD17B1 (0.36) GLAPOLBGAATSHRKIF11
SCHEMBL11844970 0.72 GAA (0.54) GLAPOLBGAATSHRKIF11
SCHEMBL17563226 0.71 KIF11 (0.37) GLAPOLBGAATSHRKIF11
SCHEMBL394903 0.70 TSHR (0.41) GLAPOLBGAATSHRKIF11
SCHEMBL7714355 0.69 ALOX15 (0.55) POLBGAAKIF11KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed
EP-0708149-A1 Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-24 EP disclosed