Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017273 | 0.81 | MMP12 (0.51) | TSHRSMN1; SMN2MMP12MMP13POLB | |
| SCHEMBL8922000 | 0.79 | LMNA (0.40) | TSHRSMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL5025501 | 0.77 | MMP12 (0.69) | TSHRSMN1; SMN2MMP12MMP13POLB | |
| SCHEMBL13851659 | 0.76 | TBXAS1 (0.56) | SMN1; SMN2MAPTHSD17B10TBXAS1 | |
| SCHEMBL7552548 | 0.74 | TBXAS1 (0.64) | SMN1; SMN2MAPTTBXAS1 | |
| SCHEMBL27412442 | 0.73 | TBXAS1 (0.65) | TSHRSMN1; SMN2MAPTTBXAS1 | |
| SCHEMBL709703 | 0.71 | MMP12 (0.67) | TSHRSMN1; SMN2MMP12MMP13POLB | |
| SCHEMBL7011872 | 0.71 | KEAP1 (0.52) | TBXAS1HCAR2 | |
| SCHEMBL29308029 | 0.70 | MMP12 (0.65) | SMN1; SMN2MMP12MMP13POLBGMNN | |
| SCHEMBL8666564 | 0.70 | HSD17B10 (0.73) | TSHRMMP12MMP13POLBGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633379-A | N-METHYLASPARTIC ACID ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |