Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308597 | 0.83 | MEN1 (0.72) | L3MBTL1MAPK1LMNAMEN1KMT2A | |
| SCHEMBL7734705 | 0.81 | MAPK1 (0.74) | L3MBTL1MAPK1LMNAMEN1KMT2A | |
| SCHEMBL29952405 | 0.80 | CASP3 (0.54) | L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8925483 | 0.79 | HPGD (0.68) | L3MBTL1MAPK1LMNAMEN1KMT2A | |
| SCHEMBL9753459 | 0.79 | TDP1 (0.50) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3020364 | 0.77 | L3MBTL1 (0.60) | L3MBTL1MAPK1LMNAMEN1KMT2A | |
| SCHEMBL9688935 | 0.77 | PKM (0.52) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22022864 | 0.76 | ACLY (0.75) | L3MBTL1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1309256 | 0.75 | MEN1 (0.78) | L3MBTL1MAPK1LMNAMEN1KMT2A | |
| SCHEMBL1306728 | 0.75 | MEN1 (0.65) | L3MBTL1MAPK1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |