Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.34 |
| ▸ | CDC25A | P30304 | 2/20 | 0.34 |
| ▸ | CDC25B | P30305 | 2/20 | 0.34 |
| ▸ | PRNP | P04156 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924494 | 0.68 | KEAP1 (0.38) | APEX1HSD17B10CDC25ACDC25BNPSR1 | |
| SCHEMBL12365457 | 0.60 | ALDH1A1 (0.53) | APEX1TSHRALDH1A1CYP2C19HPGD | |
| SCHEMBL1930794 | 0.60 | ALDH1A1 (0.77) | TSHRALDH1A1LMNAKMT2AMAP2K7 | |
| SCHEMBL13273793 | 0.59 | PRNP (0.46) | APEX1TSHRALDH1A1HSD17B10PRNP | |
| Succinic Acid SCHEMBL2578311 | 0.58 | LMNA (0.50) | TSHRLMNAMAPK1KDM4EL3MBTL1 | |
| SCHEMBL95982 | 0.58 | TSHR (1.00) | APEX1TSHRHSD17B10LMNAKMT2A | |
| Water SCHEMBL11221867 | 0.56 | TSHR (0.93) | APEX1TSHRHSD17B10LMNAKMT2A | |
| Ammonia Solution, Strong SCHEMBL8958644 | 0.56 | TSHR (0.93) | APEX1TSHRHSD17B10LMNAKMT2A | |
| E388 SCHEMBL28696 | 0.56 | LMNA (1.00) | APEX1TSHRALDH1A1HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL10457214 | 0.56 | TSHR (0.93) | APEX1TSHRHSD17B10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |