SCHEMBL8925820

SCHEMBL8925820

Cn1cc(C2=CC(=O)N(c3c(C4CCNCC4)[nH]c4cccc(CC(F)(F)C(F)(F)C(F)(F)F)c34)C2=O)c2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CAMK2D Q13557 2/20 0.35
PRKCG P05129 1/20 0.35
PRKCB P05771 1/20 0.35
PRKCA P17252 1/20 0.35
PRKCH P24723 1/20 0.35
PRKCE Q02156 1/20 0.35
PRKCZ Q05513 1/20 0.35
PRKCD Q05655 1/20 0.35
CAMK2B Q13554 1/20 0.35
CAMK2G Q13555 1/20 0.35
CAMK2A Q9UQM7 1/20 0.35
SLC6A4 P31645 1/20 0.34
PTPRC P08575 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8925816 0.79 CAMK2D (0.38) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL8920200 0.74 PRKCG (0.43) CAMK2DPRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL8919122 0.74 PRKCB (0.43) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL8523454 0.69 PTPRC (0.40) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL8923641 0.66 CAMK2D (0.37) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL22534426 0.65 GSK3B (0.49) PRKCAPTPRC
SCHEMBL8619768 0.63 PIM1 (0.43) CAMK2DPRKCAPTPRC
Hydrochloric Acid SCHEMBL8653000 0.62 PTPRC (0.40) PRKCGPRKCBPRKCAPRKCHPRKCE
SCHEMBL8482610 0.62 PRKACA (0.47) PRKCGPRKCBPRKCAPRKCHPRKCE
SCHEMBL8482795 0.62 CCNT1 (0.44) CAMK2DPRKCAPTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5672618-A TREATING DIABETIC COMPLICATIONS ELI LILLY AND COMPANY (US) 1997-09-30 US disclosed