Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2353823 | 0.85 | HTR2A (0.33) | HTR2A | |
| Hydrochloric Acid SCHEMBL3783189 | 0.85 | HTR2A (0.35) | HTR2APOLBCYP1A2CYP3A4GAA | |
| Hydrochloric Acid SCHEMBL8927344 | 0.83 | POLB (0.31) | POLBCYP1A2CYP3A4GAACYP2D6 | |
| Bromide SCHEMBL7205884 | 0.82 | HTR2A (0.35) | HTR2APOLB | |
| SCHEMBL8093928 | 0.79 | POLB (0.30) | POLB | |
| Hydrochloric Acid SCHEMBL8854555 | 0.73 | HTR2A (0.36) | HTR2ACYP1A2CYP3A4GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL7203692 | 0.70 | HTR2A (0.38) | HTR2ACYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL7203180 | 0.70 | HTR2A (0.39) | HTR2A | |
| Hydrochloric Acid SCHEMBL7095854 | 0.70 | POLB (0.34) | HTR2APOLBCYP1A2CYP3A4GAA | |
| SCHEMBL8366223 | 0.68 | POLB (0.35) | HTR2APOLBCYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627245-A | Process for the preparation of a syndiotactic propylene copolymer | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | claimed |
| US-5627245-A | Process for the preparation of a syndiotactic propylene copolymer | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5539066-A | Process for the preparation of syndiotactic polyolefins having a broad molecular weight distribution | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-23 | — | — | US | disclosed |
| US-5371158-A | Bulk polymerization using specific metallocene catalysts for the preparation of cycloolefin polymers | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | disclosed |