SCHEMBL2177285

SCHEMBL2177285

Cc1ccc(Nc2c(S(=O)(=O)O)ccc3ccccc23)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 2/20 0.50
HKDC1 Q2TB90 2/20 0.50
KDM1A O60341 1/20 0.48
MAPT P10636 2/20 0.45
CDC25B P30305 1/20 0.45
UBE2I P63279 1/20 0.45
SAE1 Q9UBE0 1/20 0.45
UBA2 Q9UBT2 1/20 0.45
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
RECQL P46063 1/20 0.45
CASP6 P55212 1/20 0.45
KMT2A Q03164 1/20 0.45
ELAVL1 Q15717 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP1A2 P05177 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL714638 0.88 TTR (0.51) SNCAHKDC1KDM1AMAPTCDC25B
SCHEMBL28790106 0.87 SNCA (0.57) SNCAHKDC1KDM1AMAPTKDM4E
SCHEMBL31389122 0.84 HKDC1 (0.49) SNCAHKDC1KDM1AMAPTCDC25B
SCHEMBL28790103 0.82 TNNI3 (0.45) SNCAHKDC1MAPTCDC25BKDM4E
SCHEMBL1715599 0.80 MEN1 (0.45) HKDC1MAPTSAE1UBA2KDM4E
SCHEMBL29864695 0.80 MEN1 (0.45) HKDC1MAPTSAE1UBA2KDM4E
SCHEMBL8928013 0.79 MAPT (0.40) HKDC1KDM1AMAPTKDM4EMEN1
SCHEMBL8333457 0.78 HKDC1 (0.41) HKDC1KDM1AMAPTKDM4EMEN1
SCHEMBL5051397 0.77 SNCA (0.53) SNCAHKDC1KDM1AMAPTCDC25B
SCHEMBL5073467 0.77 SNCA (0.51) SNCAHKDC1KDM1AMAPTCDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12458605-B2 Lipid nanoparticle NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2025-11-04 US disclosed
WO-2025129333-A1 LIPID NANOPARTICLES HAVING NON-POLAR LIPIDS FOR NUCLEIC ACID DELIVERY TO THE LIVER NANOVATION THERAPEUTICS INC. (CA) 2025-06-26 WO disclosed
WO-2024216026-A1 COMPOSITIONS AND METHODS FOR DELIVERING CARGO TO CELLS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2024-10-17 WO disclosed
US-20240024252-A1 LIPID NANOPARTICLE NITTO DENKO CORPORATION (JP) 2024-01-25 US disclosed
WO-2023191050-A1 PHARMACEUTICAL COMPOSITION FOR DELIVERY TO CANCER, OR IMMUNOSTIMULATING COMPOSITION 日東電工株式会社 2023-10-05 WO disclosed
EP-4223314-A1 LIPID NANOPARTICLE National University Corporation Hokkaido University (JP) 2023-08-09 EP disclosed
CN-116367718-A Lipid nanoparticles 国立大学法人北海道大学 2023-06-30 CN disclosed
US-11666534-B2 Methods of administering lipid formulations with viral immunogens GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2023-06-06 US disclosed
WO-2022071582-A1 LIPID NANOPARTICLE 国立大学法人北海道大学 2022-04-07 WO disclosed
EP-3676394-A1 NICKING AND EXTENSION AMPLIFICATION REACTION (NEAR) OF RESPIRATORY SYNCYTIAL VIRUS SPECIES Ionian Technologies Inc. (US) 2020-07-08 EP disclosed
WO-2019046610-A1 NICKING AND EXTENSION AMPLIFICATION REACTION (NEAR) OF RESPIRATORY SYNCYTIAL VIRUS SPECIES IONIAN TECHNOLOGIES INC. (US) 2019-03-07 WO disclosed
WO-2011081896-A2 PLASMONIC ELECTRICITY UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) 2011-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240024252-A1 LIPID NANOPARTICLE LIPC, ACOX1, ABCB4 SNCA 2921/4885HKDC1 2037/4885KDM1A 3455/4885
US-12458605-B2 Lipid nanoparticle LIPC, ACOX1, ABCB4 SNCA 2926/4885HKDC1 2148/4885KDM1A 3492/4885
US-11666534-B2 Methods of administering lipid formulations with viral immunogens STING1, CGAS, PLA2G2A SNCA 4380/4885HKDC1 3736/4885KDM1A 1181/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.