Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 8/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.55 |
| ▸ | NQO2 | P16083 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928099 | 0.86 | MTNR1B (0.73) | MTNR1BMTNR1A | |
| SCHEMBL8928098 | 0.82 | MTNR1A (0.63) | MTNR1A | |
| SCHEMBL8928245 | 0.81 | MTNR1A (0.56) | MTNR1BMTNR1AKDM4EHSD17B10 | |
| SCHEMBL25335984 | 0.79 | CYP2D6 (0.68) | CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL8928123 | 0.77 | MTNR1A (0.73) | MTNR1BMTNR1ANQO2CYP2D6CYP2C9 | |
| SCHEMBL14430371 | 0.76 | POLB (0.61) | MTNR1BMTNR1AHSD17B10 | |
| SCHEMBL32684170 | 0.74 | MTNR1A (0.63) | MTNR1BMTNR1ANQO2KDM4ETP53 | |
| SCHEMBL793987 | 0.74 | GLA (0.63) | MTNR1BMTNR1AKMT2A | |
| SCHEMBL8928133 | 0.74 | MTNR1A (0.67) | MTNR1BMTNR1ANQO2MAPTCYP2D6 | |
| SCHEMBL19304105 | 0.74 | CHRM2 (0.54) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | claimed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | claimed |
| US-5661185-A | AN ALKOXYPHENYL-ALKYLUREA COMPOUND TREATING SLEEP DISORDER | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5597651-A | Rubber-polyester composites including polystyrene-polyester copolymers | HOECHST CELANESE CORP. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | disclosed |